Roman Fischer Selected Research

Type II Tumor Necrosis Factor Receptors

9/2021	Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice.
1/2021	The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation.
1/2020	TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice.
10/2019	Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis.
1/2019	Continuous infusion of an agonist of the tumor necrosis factor receptor 2 in the spinal cord improves recovery after traumatic contusive injury.
1/2019	TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes.
11/2018	Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis.
10/2016	Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration.
1/2015	Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF.
2/2014	Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor.

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Roman Fischer Research Topics

Disease

19	Neoplasms (Cancer) 01/2021 - 05/2011
16	Inflammation (Inflammations) 01/2022 - 01/2014
8	Hypoxia (Hypoxemia) 01/2022 - 09/2011
6	Rheumatoid Arthritis 01/2021 - 02/2012
5	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 11/2021 - 01/2018
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 01/2011
5	Infections 01/2020 - 03/2013
5	Multiple Sclerosis 01/2020 - 01/2014
5	Autoimmune Diseases (Autoimmune Disease) 11/2018 - 02/2012
4	Parkinson Disease (Parkinson's Disease) 01/2021 - 01/2011
4	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2020 - 01/2014
4	Genomic Instability 01/2019 - 11/2016
4	Ankylosing Spondylitis 02/2014 - 05/2011
3	Osteoarthritis 01/2022 - 12/2017
3	Pain (Aches) 01/2021 - 01/2019
3	Dental Calculus 01/2021 - 01/2018
3	Neuralgia (Stump Neuralgia) 10/2019 - 01/2019
3	Necrosis 11/2018 - 01/2014
3	Anemia 01/2018 - 05/2011
2	Arthritis (Polyarthritis) 01/2022 - 01/2016
2	Insulin Resistance 01/2022 - 01/2020
2	Ulcerative Colitis 11/2021 - 04/2016
2	Demyelinating Diseases (Demyelinating Disease) 09/2021 - 10/2019
2	Cardiomyopathies (Cardiomyopathy) 01/2021 - 01/2016
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2021 - 04/2016
2	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2021 - 05/2011
2	Spinal Cord Injuries (Spinal Cord Injury) 01/2020 - 01/2019
2	Melanoma (Melanoma, Malignant) 01/2020 - 11/2018
2	Colorectal Neoplasms (Colorectal Cancer) 11/2019 - 02/2015
2	Stroke (Strokes) 11/2019 - 01/2017
2	Pathologic Processes 04/2019 - 01/2017
2	Breast Neoplasms (Breast Cancer) 01/2019 - 01/2017
2	Disease Progression 01/2018 - 01/2018
2	Experimental Arthritis 01/2018 - 01/2016
2	Acute-Phase Reaction 01/2018 - 01/2018
2	Chronic Obstructive Pulmonary Disease (COPD) 01/2018 - 01/2015
2	Neuroinflammatory Diseases 01/2018 - 09/2012
2	Periodontitis 12/2017 - 01/2016
2	Cysts 03/2013 - 10/2011
1	Pseudohypoaldosteronism 01/2022
1	Hypertension (High Blood Pressure) 01/2022
1	Colitis 11/2021
1	Central Nervous System Diseases (CNS Diseases) 09/2021
1	Aneurysm (Aneurysms) 01/2021
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2021
1	Bloom Syndrome 01/2021
1	Urinary Bladder Neoplasms (Bladder Cancer) 01/2021
1	Abdominal Aortic Aneurysm 01/2021
1	Alzheimer Disease (Alzheimer's Disease) 01/2021

Drug/Important Bio-Agent (IBA)

23	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2012
11	EnzymesIBA 01/2022 - 05/2011
10	Type II Tumor Necrosis Factor ReceptorsIBA 09/2021 - 02/2014
9	Biomarkers (Surrogate Marker)IBA 11/2021 - 02/2012
9	Type I Tumor Necrosis Factor ReceptorsIBA 09/2021 - 01/2014
7	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 09/2021 - 01/2015
7	Peptides (Polypeptides)IBA 01/2021 - 02/2014
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021 - 01/2011
6	CytokinesIBA 11/2021 - 09/2012
6	Biological ProductsIBA 01/2021 - 02/2015
5	Phosphotransferases (Kinase)IBA 09/2021 - 01/2016
4	Fatty Acids (Saturated Fatty Acids)IBA 01/2022 - 01/2018
4	LipidsIBA 01/2022 - 02/2015
4	Therapeutic UsesIBA 01/2020 - 01/2016
4	ProteomeIBA 01/2020 - 03/2013
4	Oxygen (Dioxygen)IBA 10/2019 - 09/2011
3	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 09/2018
3	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 11/2016
3	Milk Proteins (Milk Protein)IBA 01/2021 - 01/2018
3	Transcription Factors (Transcription Factor)IBA 01/2020 - 01/2016
3	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 10/2019 - 10/2011
2	Proline (L-Proline)FDA Link 01/2022 - 01/2020
2	Mixed Function Oxygenases (Monooxygenases)IBA 01/2022 - 09/2011
2	Glutamic Acid (Glutamate)FDA Link 09/2021 - 01/2019
2	IsotopesIBA 01/2021 - 04/2015
2	Protein Isoforms (Isoforms)IBA 01/2021 - 01/2019
2	CollagenIBA 01/2021 - 01/2020
2	Triglycerides (Triacylglycerol)IBA 01/2020 - 01/2018
2	Microphthalmia-Associated Transcription FactorIBA 01/2020 - 11/2018
2	itaconic acidIBA 01/2020 - 01/2018
2	Arginine (L-Arginine)FDA Link 11/2019 - 02/2014
2	AntigensIBA 10/2019 - 01/2018
2	Amino Acids FDA Link 11/2018 - 04/2015
2	C-Reactive ProteinIBA 01/2018 - 01/2017
2	TenascinIBA 12/2017 - 10/2016
2	VimentinIBA 12/2017 - 01/2015
2	AutoantibodiesIBA 10/2016 - 02/2012
2	Protein-Arginine DeiminasesIBA 01/2016 - 01/2015
2	OxygenasesIBA 03/2014 - 05/2011
2	Fumarate Hydratase (Fumarase)IBA 03/2013 - 10/2011
1	CeramidesIBA 01/2022
1	Metalloproteases (Metalloproteinases)IBA 01/2022
1	defactinibIBA 11/2021
1	Factor V (Coagulation Factor V)IBA 11/2021
1	InterferonsIBA 11/2021
1	CuprizoneIBA 09/2021
1	Angiotensin IIIBA 01/2021
1	ThymosinIBA 01/2021

Therapy/Procedure

14	Therapeutics 01/2021 - 11/2011
2	Radiotherapy 01/2021 - 01/2018
1	Transjugular Intrahepatic Portasystemic Shunt 01/2022